{"id":10646,"date":"2021-02-22T12:24:14","date_gmt":"2021-02-22T12:24:14","guid":{"rendered":"https:\/\/laforcedmd.com\/?p=10646"},"modified":"2022-05-03T18:00:42","modified_gmt":"2022-05-03T18:00:42","slug":"italfarmaco-update-on-givinostat","status":"publish","type":"post","link":"https:\/\/laforcedmd.com\/en\/italfarmaco-update-on-givinostat\/","title":{"rendered":"Italfarmaco provides an update on Givinostat"},"content":{"rendered":"<h4>Italfarmaco provides an update on Givinostat, an ongoing clinical program, in an oral presentation at XVIII International Conference on Duchenne and Becker Muscular Dystrophy.<\/h4>\n<p>Feb. 22, 2021, &gt;\u00a0<span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/www.businesswire.com\/news\/home\/20210222005359\/en\/\" target=\"_blank\" rel=\"noopener\">Original press release on Business Wire<\/a> <\/span>&lt;<\/p>\n<ul>\n<li><strong>Analyses of long-term study with Givinostat in Duchenne muscular dystrophy boys continue to show delayed disease progression<\/strong><\/li>\n<li><strong><span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02851797\" target=\"_blank\" rel=\"noopener\">EPYDIS<\/a><\/span> Phase 3 pivotal clinical trial continues as planned, with preliminary results expected in the second quarter of 2022<\/strong><\/li>\n<\/ul>\n<p>The<span style=\"color: #0000ff;\"> <strong><a style=\"color: #0000ff;\" href=\"https:\/\/www.biospace.com\/employer\/1820981\/italfarmaco\/\" target=\"_blank\" rel=\"noopener\">Italfarmaco Group<\/a><\/strong><\/span> announced updates on its clinical development programs with Givinostat, its proprietary histone deacetylase (HDAC) inhibitor, in boys with Duchenne Muscular Dystrophy (DMD), at the virtual XVIII International Conference on Duchenne and Becker Muscular Dystrophy. In the presentation made on February 20, 2021, Paolo Bettica, MD, Ph.D., Chief Medical Officer at the <strong>Italfarmaco Group, provided evidence that continues to show a delay in disease progression in DMD boys aged 7-11 years<\/strong> at treatment start, supported by data on the 7-year follow-up period from the long-term study with Givinostat in addition to steroid treatment.<\/p>\n<p>&nbsp;<\/p>\n<blockquote><p><b>Dr. Paolo Bettica &#8211; <\/b>\u201cWe are very encouraged to see that the long-term study with <strong>Givinostat continues to show a benefit in boys with DMD<\/strong>, which further supports its potential as a treatment. Our Phase 3 pivotal clinical study is on track and continues as planned with 179 boys recruited, and we look forward to announcing the results in the second quarter of next year. We have made significant progress despite the pandemic and instituted procedures to ensure the safety and well-being of all trial participants while being able to continuously provide access to the study drug, as well as to maintain the scientific validity and integrity of the trial. We are grateful to the clinical teams conducting the studies in all of the sites for continuing to work for the benefit of the participants.\u201d<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p>The on-going, long-term study (ClinicalTrials.gov:\u00a0<span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.clinicaltrials.gov%2Fct2%2Fshow%2FNCT03373968&amp;esheet=52382698&amp;newsitemid=20210222005359&amp;lan=en-US&amp;anchor=NCT03373968&amp;index=2&amp;md5=02b5535cec1dfd6cab20373dc045017d\" rel=\"nofollow\" shape=\"rect\">NCT03373968<\/a><\/span>) with Givinostat in boys with DMD is an extension of its Phase 2 trial (ClinicalTrials.gov: <span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT01761292&amp;esheet=52382698&amp;newsitemid=20210222005359&amp;lan=en-US&amp;anchor=NCT01761292&amp;index=3&amp;md5=ab1c62ad1fbd9297ec2f6ee5d97703bc\" rel=\"nofollow\" shape=\"rect\">NCT01761292<\/a><\/span>). <strong>The new follow-up analyses* after more than 7 years of treatment show that the mean age at loss of ambulation in DMD boys treated with Givinostat on top of corticosteroids is 16.0 years contrasted to the one in the Cooperative International Neuromuscular Research Group (CINRG) study, which was 13.4 years<\/strong> (Mc Donald et al., Lancet 2017). Moreover, the yearly rate of change of respiratory parameters such as Forced Vital Capacity % Predicted (FVC%) and Peak Expiratory Flow % predicted (PEF%) is -1.7% and 0% in contrast to the 4 to 6% yearly rate of decline in these parameters as demonstrated in natural history studies of a patient population comparable to the Givinostat cohort (Mayer\u00a0<i>et al<\/i>., Paediatr Pulmonol 2015; Henricson\u00a0<i>et al<\/i>., Muscle Nerve 2013; Abresch\u00a0<i>et al<\/i>., Neuromuscul Disord 2013; Kinane\u00a0<i>et al<\/i>., Journal of Neuromuscular Diseases 2018).<\/p>\n<p>&nbsp;<\/p>\n<blockquote><p><strong>Prof. Eugenio Mercuri<\/strong>, Professor of Paediatric Neurology at the Catholic University, Rome, Italy, commented on these results, <strong>\u201cOverall these results suggest a potential long-term beneficial effect of Givinostat in DMD boys. We look forward to the final results and remain hopeful that these results can support the registration of Givinostat for the treatment of DMD.\u201d<\/strong><\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p>In October 2020, the U.S. Food and Drug Administration (FDA) granted a Rare Pediatric Disease designation to Givinostat to treat DMD, which allows an expedited review process for new treatment modalities. The company also received an Orphan Drug designation and Fast Track designation for Givinostat from the FDA.<\/p>\n<h4>About Givinostat<\/h4>\n<p>Givinostat is an investigational drug discovered through Italfarmaco\u2019s internal research and development efforts in collaboration with Lorenzo Puri (Santa Lucia Foundation, Rome) and his team and partnerships with Telethon and Parent Project aps. It is being evaluated for safety and efficacy for the treatment of Duchenne &#8211; and Becker &#8211; Muscular Dystrophy. <strong>Givinostat inhibits histone deacetylases (HDACs). HDACs are enzymes that prevent gene translation by changing the three-dimensional folding of DNA in the cell. Studies show that Duchenne patients have higher than normal HDAC levels, which may prevent muscle regeneration and trigger inflammation. In the company\u2019s clinical study in DMD boys aged seven to less than 11 years, Givinostat was observed to slow disease progression, significantly increase muscle mass and reduce the amount of fibrotic tissue. Givinostat treatment also significantly reduced muscle tissue necrosis and fatty replacement, two additional parameters related to disease progression (Bettica <i>et al<\/i>., Neuromuscular Disorder 2016).<\/strong><\/p>\n<h4>About Italfarmaco Group<\/h4>\n<p>Italfarmaco is a specialty pharmaceutical company engaged in discovering, developing, manufacturing, and marketing branded prescription and nonprescription products in more than 60 countries on 5 continents. Italfarmaco\u2019s research and development expertise is best demonstrated through its HDAC inhibitor development programs, addressing new therapeutic treatments of specialty and rare diseases. Italfarmaco is dedicated to serving patients whose needs remain largely unmet through marketed drugs and compounds in development. <span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/www.italfarmaco.com\/en-us\/\" target=\"_blank\" rel=\"noopener\">italfarmaco.com<\/a><\/span><\/p>\n<p><em>*The results of these analyses are not published yet.<\/em><\/p>\n<h4>Canadian study locations<\/h4>\n<ul>\n<li><strong>Canada, Alberta: <\/strong>Kinsmen Research Centre &#8211; Alberta Children&#8217;s Hospital &#8211; Alberta Health Services<\/li>\n<li><strong>Canada, British Columbia:<\/strong> The University of British Columbia, Children&#8217;s and Women&#8217;s Health Centre of BC Branch<\/li>\n<li><strong>Canada, Ontario:<\/strong> Holland Bloorview Kids Rehabilitation Hospital<\/li>\n<li>Read more on <span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02851797\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov<\/a><\/span><\/li>\n<\/ul>\n<p><em>Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff.<\/em><\/p>\n<h4>About Duchenne muscular dystrophy<\/h4>\n<p>Duchenne muscular dystrophy (DMD) is a disease that almost exclusively affects boys and whose incidence is 1 in 3,500. Duchenne muscular dystrophy (DMD) will rarely affect girls. Those affected are usually diagnosed around five, but symptoms may be visible from early childhood. It is a degenerative disease of the muscles caused by a genetic mutation. The Duchenne muscular dystrophy (DMD) \u2013 for which no treatment is currently available \u2013 directly affects skeletal muscles. Without treatment, the consequences of the disease are dire for those afflicted and their families. <span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"\/?page_id=3314\" target=\"_blank\" rel=\"noopener\">Read more here<\/a><\/span>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Italfarmaco provides an update on Givinostat, an ongoing clinical program, in an oral presentation at XVIII International Conference on Duchenne and Becker Muscular Dystrophy. Feb. 22, 2021, &gt;\u00a0Original press release on Business Wire &lt; Analyses of long-term study with Givinostat in Duchenne muscular dystrophy boys continue to show delayed disease progression EPYDIS Phase 3 pivotal [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":10649,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,18],"tags":[],"class_list":["post-10646","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-treatments"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Italfarmaco provides an update on Givinostat La Force dmd<\/title>\n<meta name=\"description\" content=\"Italfarmaco provides an update on Givinostat, an ongoing clinical program, in an oral presentation at XVIII International Conference DMD BMD\" \/>\n<meta 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