{"id":6892,"date":"2018-05-31T11:08:56","date_gmt":"2018-05-31T11:08:56","guid":{"rendered":"https:\/\/laforcedmd.com\/?p=6892"},"modified":"2022-05-03T18:16:04","modified_gmt":"2022-05-03T18:16:04","slug":"stat3-new-research-treat-dmd","status":"publish","type":"post","link":"https:\/\/laforcedmd.com\/en\/stat3-new-research-treat-dmd\/","title":{"rendered":"STAT3 a new research to treat DMD"},"content":{"rendered":"<h3>Canadian Research series<\/h3>\n<p><strong>This video series of interviews features Canadian scientists who work on solutions for Duchenne muscular dystrophy (DMD). We wish to connect you \u2013 the DMD community \u2013 with these scientists. You\u2019ll be delighted to learn about their motivation and dedication to this cause. In turn, they appreciate knowing more about our community, because we\u2019re the people who are impacted by their discoveries. We hope that the interviews will help to foster an understanding of scientific concepts that aren\u2019t always easy to grasp.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><iframe loading=\"lazy\" title=\"STAT3 a new research for DMD\" width=\"1140\" height=\"641\" src=\"https:\/\/www.youtube.com\/embed\/FUK1R1tv7HQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<h3><\/h3>\n<h3>Meet the Gunning Group<\/h3>\n<p>We met and interviewed Patrick Gunning, Ph.D., who leads the Gunning Group, and one of his Ph.D. students, Yasir Raouf. Professor Gunning holds a Canada Research Chair in Medicinal Chemistry and is Director of the Centre for Medicinal Chemistry, Department of Chemical and Physical Sciences, at the University of Toronto\u2019s Mississauga campus.<\/p>\n<p>The Gunning Group is a team of scientists who pursue projects that focus on drug discovery. They work at the molecular level to design new drugs. Their goal is to develop better treatments and diagnostic options for devastating and under-explored human diseases. One of those diseases is DMD.<\/p>\n<blockquote>\n<p style=\"text-align: left;\"><strong>Dr. Gunning:\u00a0<\/strong>\u201cYasir and myself are very motivated to try and see whether a STAT drug would work in DMD,\u201d<\/p>\n<\/blockquote>\n<p>&nbsp;<\/p>\n<h3>What to know about STAT3<\/h3>\n<p>Their research targets STAT3, a protein that plays an essential role in cell regeneration. STAT3 is a transcription factor that controls or regulates, to some extent, how cells proliferate or grow and divide.<\/p>\n<p>That\u2019s very relevant to DMD, says Yasir Raouf. In DMD, muscle cell regeneration is poor. \u201cUsually in humans, when your muscle cells die, they regenerate, and you get new muscles. If you have DMD, that regeneration is slow or nonexistent.\u201d<\/p>\n<p>If you can control STAT3, you can control the regenerative capacity of muscle cells, he believes.<\/p>\n<p>&nbsp;<\/p>\n<h3>What\u2019s the timeline for development of this treatment?<\/h3>\n<p>Over the last decade, the Gunning Group developed a STAT3 drug that inhibits this protein. Over the next two years, they plan to test its effectiveness in mouse models. They will study how it affects muscle cell proliferation in mice over an extended period. For this work, they will collaborate with Dr. Michael Rudnicki, Professor and holder of a Canada Research Chair in Molecular Biology at the University of Ottawa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Words of hope for the DMD community<\/h3>\n<blockquote><p><strong>Dr. Gunning has a message for families in the DMD community:\u00a0<\/strong>\u201cIt\u2019s very important to raise awareness for this disease.\u201d<\/p><\/blockquote>\n<blockquote><p><strong>He urges families to highlight to the industry that people need help and new drugs to treat this orphan disease.\u00a0<\/strong>\u201cIf money and efforts in research are put towards this disease, I\u2019m very confident that academics like myself or industry can find something that will spare the lives of these children.\u201d<\/p><\/blockquote>\n<blockquote><p><strong>Yasir Raouf hopes that we will soon live in a world that has cured DMD.<\/strong>\u201cThat\u2019s what I hope for. That\u2019s what I work for.\u201d<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p>More about the Gunning Group: <a href=\"http:\/\/www.gunninggroup.ca\">http:\/\/www.gunninggroup.ca<\/a><\/p>\n<p>&nbsp;<\/p>\n<h3>Connect to our Canadian Research Series<\/h3>\n<p>An effective way to be informed and to receive our videos right out of the box is to\u00a0<a href=\"\/?page_id=3379\">sign up here for our newsletter.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Canadian Research series This video series of interviews features Canadian scientists who work on solutions for Duchenne muscular dystrophy (DMD). We wish to connect you \u2013 the DMD community \u2013 with these scientists. You\u2019ll be delighted to learn about their motivation and dedication to this cause. In turn, they appreciate knowing more about our community, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":6895,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-6892","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>STAT3-new-approach-to-cure-Duchenne-la-forcedmd<\/title>\n<meta name=\"description\" content=\"This video series of interviews features Canadian scientists who work on solutions for Duchenne muscular dystrophy (DMD). 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